Figure 1 | Scientific Reports

Figure 1

From: microRNA-132/212 deficiency enhances Aβ production and senile plaque deposition in Alzheimer’s disease triple transgenic mice

Figure 1

Analysis of Aβ metabolism in miR-132/212-deficient AD mice.

(a,b) ELISA of human Aβ40 and Aβ42 in hippocampal samples of 3xTg-ADWT and 3xTg-ADKO mice (n = 8–10 mice for each group, mixed gender). 6M; 6 month-old, 12M; 12 month-old, 18M; 18 month-old. (c,d) ELISA of human Aβ40 and Aβ42 in cortical samples of 3xTg-ADWT and 3xTg-ADKO mice (n = 8–10 mice for each group). 6M; 6 month-old, 12M; 12 month-old, 18M; 18 month-old. (e) Immunohistochemical detection of Aβ plaques in the forebrains of 18 month 3xTg-ADWT and 3xTg-ADKO mice (n = 3 mice for each genotype). Scale bar: 100 μm. (f) Thioflavine-S-positive stainings of Aβ plaques in the forebrains of 18 month 3xTg-ADWT and 3xTg-ADKO mice (n = 3 mice for each group). Scale bar: 100 μm. Data are presented as mean ± SEM. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001 (Student’s t-test).

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