Figure 2 | Scientific Reports

Figure 2

From: hiPSC-derived cardiomyocytes from Brugada Syndrome patients without identified mutations do not exhibit clear cellular electrophysiological abnormalities

Figure 2

Sodium current (INa) characterization in hiPSC-CMs from iCtrl1, iCtrl2, the three BrS patients iBrS1 to iBrS3 and iSCN5A.

(A) Representative traces of INa as determined by the voltage clamp protocol shown in the inset of (B). (B) Current-voltage (I-V) relationships of peak INa (mean ± SEM). (C) Boxplots depicting INa densities (median, boxes represent interquartile range, whiskers 95% interval), determined at −20 mV. *indicates significance compared to iCtrl1 and iCtrl2 (p < 0.05; Kruskal-Wallis test, followed by pairwise comparisons). (D) Voltage dependence of activation. (E) Voltage dependence of inactivation. The inset represents the voltage clamp protocol that was applied.

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