Figure 3: Time line and experimental outline for in vivo ocular tolerability experiments.
From: Predatory bacteria are nontoxic to the rabbit ocular surface
The corneas of NZW rabbits were abraded (right eye) or left intact (left eye), and exposed to drops of saline (negative control for toxicity), vancomycin (positive control for toxicity), or predatory bacteria (>107 PFU per drop). Drops were administered at 1 hour intervals, five times per day for the first 5 days. Each day the eyes were treated with fluorescein and evaluated for clinical signs of inflammation and toxicity using a MacDonald-Shadduck scoring system. The diameter of the corneal defect on the right eye was measured with a ruler.
