Figure 7: T3 reduces STAT3 activation in macrophages.
From: The Thyroid Hormone Receptors Inhibit Hepatic Interleukin-6 Signaling During Endotoxemia
(A) Western blot analysis of the indicated total and phosphorylated proteins in primary cultures of bone marrow macrophages (left) and RAW264.7 macrophages (right) pretreated with 5 nM T3 in 10% thyroid hormone-depleted serum for 36 h and then treated with 300 ng/ml LPS for the indicated time points. Full-length blots are presented in Supplementary Figure 9. (A) Levels of TNFα and IL-6 mRNA (means ± s.d) in bone marrow and RAW264.7 macrophages treated with T3 for 36 h and with LPS for the last 6 h.
