Figure 4 | Scientific Reports

Figure 4

From: The CD4+ T cell methylome contributes to a distinct CD4+ T cell transcriptional signature in Mycobacterium bovis-infected cattle

Figure 4

Hierarchical clustering of all control (C) and BTB-Infected (I) samples on the basis of differential methylation profile.

A heatmap of 84 CpG sites with methylation levels associated with TB infection status. Each included site is covered by methylated DNA sequence reads in all TB infected and control samples. Each row represents a CpG site, with columns corresponding to individual animals. Higher methylation levels are depicted in yellow and lower levels are red. The upper dendrogram illustrates the results of unsupervised hierarchical clustering of all 10 samples based on methylation patterns at these 84 CpG sites. A clear distinction of controls (labelled C) and infected animals (labelled I) is observed.

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