Table 3 List of genes known to be crucial for CD4+ T cell differentiation into effector T cell subsets during TB infection closest genes to significantly differentially methylated sites/regions.
Gene ID | Analysis Type | Percentage change in BTB infected cattle | Associated Th subset |
|---|---|---|---|
NFATC1 | 1 kb window | −32.5 | Th2 |
ASB | 1 kb window | −28.4 | Th2 |
GATA3 | 1 kb window | −41.9 | Th2 |
IRF4 | Individual CpG site | 31.9 | Th2/Treg |
RORC | 1 kb window | 29.7 | Th17 |
HOXA10 | Promoter region | −39.3 | Treg |
LRRC32 | 1 kb window | 40.4 | Treg |
ZBTB7B/ThPOK | 1 kb window | 34.5 | Promotes CD4+ differentiation |
RUNX3 | 1 kb window | −40.9 | Inhibits CD4+ differentiation, promotes Tregs |
