Figure 8
From: Free-energy studies reveal a possible mechanism for oxidation-dependent inhibition of MGL
Comparison of the FES profiles of hMGL modelled with C208 mutated to alanine (a), with C208 oxidized to sulfenic acid (b), with both C201 and C208 oxidized to sulfenic acid (c) and with C208 and F209 involved in the formation of a sulfenamide. Black diamonds mark the CVs values measured for the crystal structure of hMGL in its open conformation (d).
