Figure 5
From: Control of cortex development by ULK4, a rare risk gene for mental disorders including schizophrenia
Ulk4 Knockdown significantly reduces neurite ramification.
(A–D) 2-D reconstruction of GFP-labelled neurons in control (A), layers II–III of shRNA268 knockdown cortex (B), deeper layers of shRNA268 knockdown cortex (C) and shRNA269 knockdown cortex (D). (E) Sholl analysis shows that neurons in Ulk4 knockdown cortex present poorly-developed neurite arborization. Forty-one cells were reconstructed from 6 control brains, 30 cells were from layers II–III of 3 shRNA268 brains, 33 cells from deeper layers of 4 shRNA268 brains and 23 cells from 3 shRNA269 brains; Two-tailed student’s t tests. **p < 0.01, *p < 0.05.
