Figure 1 | Scientific Reports

Figure 1

From: Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE−/− mice

Figure 1

Comparison of atherosclerosis in 12-weeks old ApoE−/− and ApoE−/−Adams4−/− mice.

(a) Photos of the aortic arch in wildtype, ApoE−/− and ApoE−/−Adams4−/− mice. Arrowhead indicates the brachiocephalic artery region with prominent lesion. (b) en face ORO stained main aortic tree (from the ascending aorta to the iliac bifurcation devoid of any branches) of 12-weeks old mice. (c) Quantification of the ORO positive area represented as percentage of total arterial trunk area (n = 8 for all ApoE−/− and ApoE−/−Adams4−/− mice, n = 4 for C57BL/6J male control mice). Values shown are mean ± SEM.

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