Scientific Reports

Table 1 Plaque characteristics in brachiocephalic artery (n = 5 in all groups, with 5 sections per mouse).

From: Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE^−/− mice

	12 week old mice				18 week old mice
	Male		Female		Male		Female
Variable	ApoE^−/−	ApoE^−/−Adamts4^−/−	ApoE^−/−	ApoE^−/−Adamts4^−/−	ApoE^−/−	ApoE^−/−Adamts4^−/−	ApoE^−/−	ApoE^−/−Adamts4^−/−
Plaque Area (0.1× mm²)	1.34 ± 0.31	0.91 ± 0.12*	1.00 ± 0.23	0.91 ± 0.11	1.66 ± 0.27	1.08 ± 0.18*	1.58 ± 0.25	1.03 ± 0.20*
Fibrous Cap (μm)	13.25 ± 0.37	15.83 ± 1.41	10.68 ± 0.83	11.88 ± 0.62	10.20 ± 0.39	14.71 ± 1.03*	8.78 ± 0.52	13.15 ± 0.7*
Necrotic Core (0.1× mm²)	0.19 ± 0.02	0.06 ± 0.04	0.06 ± 0.01	0.08 ± 0.01	0.46 ± 0.02	0.22 ± 0.02	0.43 ± 0.01	0.24 ± 0.01
Cap/Core Ratio	0.09 ± 0.02	0.14 ± 0.03	0.07 ± 0.01	0.07 ± 0.02	0.05 ± 0.01	0.09 ± 0.01*	0.04 ± 0.01	0.08 ± 0.01*
Lipid content (0.1× mm²)	0.66 ± 0.02	0.23 ± 0.04	0.48 ± 0.05	0.42 ± 0.03	0.89 ± 0.09	0.28 ± 0.03	0.78 ± 0.18	0.24 ± 0.02
Lipid content (%)	50.72 ± 2.28	25.81 ± 4.55	48.76 ± 5.57	47.09 ± 4.06	56.15 ± 5.5	25.51 ± 2.55	52.14 ± 11.86	23.95 ± 2.99
CD68+ Area (0.1× mm²)	0.56 ± 0.06	0.25 ± 0.02	0.35 ± 0.02	0.33 ± 0.06	0.66 ± 0.08	0.19 ± 0.05	0.63 ± 0.10	0.19 ± 0.03
CD68+ Area (%)	43.64 ± 5.14	28.69 ± 2.05	35.00 ± 1.50	36.94 ± 7.28	41.44 ± 5.16	17.70 ± 5.03	42.08 ± 6.42	19.10 ± 3.11
SMA+ Area (0.1× mm²)	0.70 ± 0.05	0.50 ± 0.06	0.52 ± 0.01	0.48 ± 0.01	0.76 ± 0.05	0.70 ± 0.03	0.68 ± 0.06	0.63 ± 0.05
SMA+ Area (%)	54.25 ± 3.45	55.12 ± 6.51	52.72 ± 1.40	54.32 ± 1.92	47.20 ± 3.27	63.94 ± 3.14	45.3 ± 3.76	62.53 ± 5.91
Collagen Content (0.1× mm²)	0.75 ± 0.09	0.52 ± 0.05	0.56 ± 0.03	0.52 ± 0.06	0.72 ± 0.08	0.69 ± 0.05	0.50 ± 0.06	0.56 ± 0.14
Collagen Content (%)	57.59 ± 7.13	58.26 ± 6.00	55.55 ± 3.82	58.68 ± 7.19	45.16 ± 5.24	62.82 ± 4.20	33.31 ± 4.06	56.40 ± 14.23
Vulnerability Index	0.86 ± 0.15	0.49 ± 0.07**	0.78 ± 0.06	0.75 ± 0.11	1.06 ± 0.13	0.34 ± 0.05**	1.22 ± 0.31	0.37 ± 0.07**

Data are presented as Mean ± SEM. *p < 0.05, **p < 0.01.

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