Figure 1

Cancer cell-targeting ability of Bmattacin2.
Cells were treated with culture medium (odd numbers) or 2 μM of Bmattacin2 (even numbers) for 24 hours. (a) Cell surface morphology was observed by scanning electronic microscopy. Bar = 10 μm. (b) The cellular nucleus was stained by DAPI. Bar = 50 μm. (c) The cellular skeleton (actin) was stained by TRITC-phalloidin. Bar = 50 μm. (d) Human colon normal cells (FHC) and cancer cells (HCT116) were subjected by Bmattacin2 from 1 to 12 μM for 24 hours and cell viabilities were evaluated by MTS assay. (e) Fetal foreskin fibroblasts (HFF-1) and skin malignant melanoma cells (A375) served as another pair of comparison.