Figure 1
From: Genetic markers of pigmentation are novel risk loci for uveal melanoma
The regional plot of associations at HERC2/OCA2 locus with UM risk.
The most significant associations at the HERC2/OCA2 locus identified in this study were analyzed using imputation-based fine mapping. The genotyped variants (diamonds) were imputed (circles) with an INFO score >0.5. The strength of association with UM risk is displayed as [−log10(p)] versus chromosomal position (Mb). Variants are colored according to LD with rs12913832 calulated from 1000 Genomes Project Phase 3 using the data from European ancestry population (N = 503). Associations were noted for imputed variant, rs1667394 (r2 = 0.48 with rs12913832), previously reported in a GWAS on eye color19.
