Table 3 Summary results of peripheral BDNF levels in persons with ASD and healthy controls.
Variables | No. of comparisions | No. of subjects | Meta-analysis | Heterogeneity | Test for subgroup differences | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
ASD | Controls | SMD | 95% CI | P-value | I2 | P-value | I2 | P-value | |||
Biomaterial | |||||||||||
Serum | 13 | 985 | 1526 | 0.58 | 0.11 | 1.04 | 0.02 | 96 | <0.001 | 81.6 | 0.02 |
Plasma | 1 | 146 | 50 | 1.27 | 0.92 | 1.61 | <0.001 | Not applicable | Not applicable | ||
Condition | |||||||||||
ASD | 5 | 538 | 974 | 0.64 | 0.1 | 1.19 | 0.02 | 92 | <0.001 | 0 | 0.82 |
autism | 9 | 593 | 602 | 0.55 | −0.03 | 1.13 | 0.06 | 94 | <0.001 | ||
Subject age | |||||||||||
Childhood | 10 | 1010 | 1295 | 0.78 | 0.31 | 1.26 | 0.001 | 96 | <0.001 | 0 | 0.42 |
Adulthood | 4 | 121 | 281 | 0.04 | −1.72 | 1.8 | 0.97 | 97 | <0.001 | ||
Analytical technology | |||||||||||
ELISA | 11 | 619 | 622 | 0.66 | 0.12 | 1.2 | 0.02 | 94 | <0.001 | 96.6 | <0.001 |
Luminex | 3 | 470 | 920 | −0.03 | −0.14 | 0.08 | 0.56 | 0 | 0.84 | ||
RIAC | 1 | 69 | 54 | 1.57 | 1.16 | 1.98 | <0.001 | Not applicable | Not applicable | ||
Subject age & analytical technology | |||||||||||
Childhood | |||||||||||
ELISA | 7 | 498 | 341 | 0.93 | 0.54 | 1.33 | <0.001 | 85 | <0.001 | 97.2 | <0.001 |
Luminex | 3 | 470 | 920 | −0.03 | −0.14 | 0.08 | 0.56 | 0 | 0.84 | ||
RIAC | 1 | 69 | 54 | 1.57 | 1.16 | 1.98 | <0.001 | Not applicable | Not applicable | ||
Adulthood | |||||||||||
ELISA | 4 | 121 | 281 | 0.04 | −1.72 | 1.8 | 0.97 | 97 | <0.001 | Not applicable | Not applicable |
