Table 3 Logistic regression analysis of VDR polymorphisms in asymptomatic and chronic Chagas cardiomyopathy (CCC) individuals. including age as covariate.
SNP | 1|2 | Group (N) | Genotype. N (%) | MAF % | Allele test/Age | ||||
|---|---|---|---|---|---|---|---|---|---|
1|1 | 1|2 | 2|2 | P | PFDR | OR [95% CI] | ||||
rs731236 | G|A | Asymptomatic (170) | 17 (10.00) | 69 (40.59) | 84 (49.41) | 30.29 | |||
CCC (375) | 26 (6.93) | 159 (42.40) | 190 (50.67) | 28.13 | 0.4406 | 0.4633 | 0.89 [0.67–1.19] | ||
rs7975232 | C|A | Asymptomatic (164) | 28 (17.07) | 88 (53.66) | 48 (29.27) | 43.90 | |||
CCC (368) | 69 (18.75) | 203 (55.16) | 96 (26.09) | 46.33 | 0.4304 | 0.4633 | 1.12 [0.84–1.49] | ||
rs1544410 | T|C | Asymptomatic (168) | 16 (9.52) | 72 (42.86) | 80 (47.62) | 30.95 | |||
CCC (367) | 27 (7.36) | 155 (42.23) | 185 (50.41) | 28.47 | 0.4633 | 0.4633 | 0.90 [0.67–1.20] | ||
rs2228570 | A|G | Asymptomatic (170) | 21 (12.35) | 75 (44.12) | 74 (43.53) | 34.41 | |||
CCC (372) | 69 (16.67) | 192 (51.61) | 118 (31.72) | 42.47 | 4.46E-03 | 0.0178 | 1.51 [1.14–2.00] | ||
