Figure 8

EP6 secondary structure.
(a) Plot of the differences between the observed alpha proton chemical shifts and the corresponding random coil values (∆δHα) versus the amino acid sequence of free EP6 (blue) and of EP6 in the presence of VEGFR1D2 (red). (b) Sequence representation of EP6 secondary structure. Residues showing the biggest STD effects are highlighted in blue while those showing lower STD effects are highlighted in cyana.