Figure 1 | Scientific Reports

Figure 1

From: Liver Gene Expression Profiles Correlate with Virus Infection and Response to Interferon Therapy in Chronic Hepatitis B Patients

Figure 1

Characterization of the intrahepatic transcription signature associated with necroinflammation of CHB.

(A) 132 up-regulated and 39 down-regulated genes were differentially expressed between BRB and BRA. Representative genes up-regulated in the BRB samples are depicted. (B) GSEA analysis of pathways enriched in the livers of CHB-infected patients. Twenty-eight functions and pathways, which were derived from the gene sets of Biocarta pathway, gene ontology and transcription factors, were enriched in the BRB samples. (C) Venn diagram illustrating the number of significant up- and down-regulated genes in the BRB samples of testing and validation sets.

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