Figure 4 | Scientific Reports

Figure 4

From: Liver Gene Expression Profiles Correlate with Virus Infection and Response to Interferon Therapy in Chronic Hepatitis B Patients

Figure 4

Characterization of the intrahepatic transcriptional signature associated with response to IFNα therapy.

A total of 118 up-regulated genes were identified in the comparison of BR and BN. The top 5 (A) and other selected significant (B) up-regulated genes are depicted. (C) Functional annotation analysis of the 118 up-regulated genes in the BR group. (D) Graphical view of the enrichment of the 118 up-regulated genes in an independent validation set, GSE27555, by GSEA (p = 0.038). (E) The enrichment scores of the predictive gene signature, which was constructed by the top 25 up-regulated genes, of responders (R) were significantly higher than those of the non-responders (N) in GSE27555 (p = 0.015). (F) Receiver operator characteristic (ROC) analysis of the 25 gene signature in GSE27555.

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