Table 3 Prognostic factors associated with overall survival in cohort 1 using univariate and multivariable analyses (N = 378).

From: Pretreatment neutrophil-to-lymphocyte ratio and its dynamic changes are associated with the overall survival in advanced cancer patients undergoing palliative care

Prognostic factors

Univariate analyses

Multivariate analysis

Unadjusted HR (95% CI)

P

Adjusted HR (95% CI)

P

Gender (Female vs. Male)

1.038 (0.829~1.299)

0.746

  

Age (≥65 vs. <65)

1.083 (0.866~1.355)

0.484

  

Tumor stage (IV vs. III)

5.441 (2.687~11.020)

<0.001

5.154 (2.409~10.03)

<0.001

Primary tumor site

0.880 (0.792~0.977)

0.016

0.993 (0.893~1.104)

0.896

Palliative care (PCR vs. BSC)

0.432 (0.328~0.569)

<0.001

0.630 (0.468~0.847)

0.002

Family history (Yes vs. No)

1.174 (0.921~1.498)

0.195

  

Smoke history (Yes vs. No)

0.856 (0.663~1.105)

0.233

  

Nutrient (Abnormal vs. Normal)

1.732 (1.336~2.246)

<0.001

1.141 (0.866~1.502)

0.349

Concomitant disease (Yes vs. No)

1.016 (0.810~1.275)

0.891

  

Hospital stay (≤14 vs. >14 days)

0.995 (0.794~1.246)

0.962

  

Albumin level

0.943 (0.926~0.960)

<0.001

0.956 (0.937~0.976)

<0.001

NLR (HNLR vs. LNLR)

1.377 (1.049~1.806)

0.020

1.514 (1.125~2.038)

0.006

  1. NLR: neutrophil-to-lymphocyte ratio; HR: hazard ratio; CI: confidence interval; PCR: palliative chemoradiotherapy; BSC: best supportive care. LNLR: low NLR (pretreatment NLR ≤ 3); HNLR: high NLR (pretreatment NLR > 3).