Figure 6: Injection of Mesp1-CPCs into post-MI hearts led to improved cardiac function and survival.

(A) The timeline of the study. (B) Improved survivability of MI hearts injected with Mesp1-CPCs. Kaplan-Meier survival analysis of mouse cohorts. Mice were monitored daily for survival data analysis. The cohorts included sham-operated control mice (n = 7), myocardial infarcted mouse injected with PBS media (MI + PBS) control mice (n = 9), and myocardial infarcted mouse injected with Mesp1-CPCs (MI + CPCs) experimental mice (n = 8); p < 0.05, Log-rank (Mantel-Cox) test. (C–G) Restored cardiac function of MI hearts injected with Mesp1-CPCs. Cardiac magnetic resonance imaging (MRI) of mice at 1 week and 6 weeks following induction of MI plus intramyocardial injection of the CPCs. Control groups include sham-operated mice, MI-operated mice injected with PBS and un-operated control mice. (C) Left ventricular ejection fraction (LV-EF). (D) Left ventricular end-systolic volume (LV-ESV). (E) Left ventricular end-diastolic volume (LV-EDV). (F) Left ventricular stroke volume. (G) MRI images during systole and diastole at 1 week and 6 weeks post-MI. Data are expressed as the mean ± S.E.M.; sham (n = 6; 1-week) and (n = 7; 6-weeks), MI+PBS (n = 6; 1-week) and (n = 4; 6-weeks), MI+CPC (n = 7; 1-week) and (n = 7; 7-weeks); NS = No Surgery controls (n = 4; 6-weeks); *p < 0.05, **p < 0.005, ***p < 0.0005.