Figure 7: Survival and differentiation of Mesp1-CPCs in post-MI hearts.
From: Mesp1 Marked Cardiac Progenitor Cells Repair Infarcted Mouse Hearts
(A) EYFP+ CPCs contribute to cardiac myocytes in the border zone. (B) EYFP+ CPCs cannot differentiate into sarcomeric cardiac myocytes in the infarct zone. (C) EYFP+ CPCs differentiate into vascular smooth muscle cells in the border zone. (D) EYFP+ CPCs differentiate into vascular smooth muscle cells in the infarct zone. (E) EYFP+ CPCs differentiate into vascular endothelial cells in the border zone. (F) EYFP+ CPCs differentiate into vascular endothelial cells in the infarct zone. (G) The distribution of CM, SMC and EC differentiation from EYFP+ cells in post-MI hearts. (H) EYFP+ CPCs are proliferative in the border zone. In control experiments, we did not observed any GFP+/Ki67+ cells within the border zone of post-MI hearts that were injected with MI+PBS (Supplemental Figure S8).
