Figure 3: Association study of metabolomics and genomics.

(a) Manhattan plots for metabolic traits. The strength of association with plasma metabolite concentrations for the five loci is shown based on the results from the association study for all 512 samples (Table 1). The line indicates a suggestive genome-wide significance level with a P-value of 7.08 × 10⁻⁹. (b–f) Regional association plots for significant loci reported in Table 1. Statistical Significance of associated SNPs is plotted on the −log₁₀(P-value) scale as a function of chromosomal position (NCBI 37). The identified causal SNP at each locus is shown in purple. Correlation of the causal SNP to other SNPs at each locus is shown on a scale from minimal (blue) to maximal (red). Estimate recombination rate are also shown.