Figure 6: In vivo antitumor activity and toxicopathological examination. | Scientific Reports

Figure 6: In vivo antitumor activity and toxicopathological examination.

From: A Novel Nitrobenzoate Microtubule Inhibitor that Overcomes Multidrug Resistance Exhibits Antitumor Activity

Figure 6

(a) Antitumor efficacy of IMB5046 in KB xenograft model and body weight of tumor-bearing mice during the experiment. IMB5046 (30, 10 and 15 mg/kg) and vehicle were given on days 0–4 & 7–11. Vincristine (1 mg/kg) was administrated on days 0 & 7. Data are presented as mean ± SD (n = 7). *P < 0.05 versus the vehicle group. (b) Antitumor efficacy of IMB5046 in H460 xenograft model and body weight of tumor-bearing mice. IMB5046 (10, 15 and 20 mg/kg) and vehicle were given on days 0–4 & 7–11. Colchicine (0.5 mg/kg) was administrated on days 0 & 7. Data are presented as mean ± SD (n = 5). *P < 0.05 versus the vehicle group. (c) Histopathological examination (hematoxylin and eosin stain) of mice treated with IMB5046 (20 mg/kg). No toxicological damage was found in the small intestine, stomach, bone marrow and heart. Scale bar, 50 μm.

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