Figure 4: Hemolysis, cytotoxicity and cyclic-AMP accumulation upon α-MSH and designed analogues treatment. | Scientific Reports

Figure 4: Hemolysis, cytotoxicity and cyclic-AMP accumulation upon α-MSH and designed analogues treatment.

From: Enhanced Cationic Charge is a Key Factor in Promoting Staphylocidal Activity of α-Melanocyte Stimulating Hormone via Selective Lipid Affinity

Figure 4

In (a) concentration-dependent hemolysis induced upon 1 h incubation of mouse RBCs with peptides. In (b) % cytotoxicity against 3T3 murine fibroblast cell line at 50 μM peptide concentration. In (c) induced accumulation of cyclic-AMP in B16 melanocytes on exposure to different concentrations of α-MSH and KKK-MSH. Each assay was done in triplicate on three different days and each data point represents mean ± S.D.

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