Figure 4: Treatment with miR-214 inhibitor ameliorated the glomerular mesangial expansion in db/db mice.
From: Cross talk between miR-214 and PTEN attenuates glomerular hypertrophy under diabetic conditions
(A) UAE in db/db mice. (B) mRNA expresion of miR-214 in glomeruli. (C) Representative images of PAS staining for glomerular mesangial expansion in mice (original magnification ×400). Scale bars: 20 μm. (D) Quantitative analysis of mesangial score in mice. (E) Representative electron micrographs in mice (original magnification ×10000). Scale bars: 2 μm. The arrows marked some mesangial areas. db/m, db/m control mice; db/db, diabetic db/db mice; ScRNA, db/db mice treated with miR-214 scramble; anti-miR-214, db/db mice treated with miR-214 inhibitor. All data were expressed as means ± SD, ▲p < 0.05 vs. db/db group, ★p < 0.05 vs. ScRNA group.
