Figure 7: The role of CREB in TDCA-induced NOX5-S expression. | Scientific Reports

Figure 7: The role of CREB in TDCA-induced NOX5-S expression.

From: Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett’s Esophageal Adenocarcinoma Cells

Figure 7

(A) TDCA treatment (10−11 M) significantly increased phosphorylation of CREB in a time-dependent manner in FLO-1 cells, indicating that TDCA may activate CREB. B) TDCA significantly increased NOX5-S mRNA levels, an increase which was significantly decreased by knockdown of CREB, suggesting that CREB may mediate TDCA-induced increase in NOX5-S expression. N = 4, ANOVA *P < 0.05, compared with Control siRNA group; **P < 0.02, compared with Control siRNA plus TDCA group.

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