Figure 8: The role of CREB in TDCA-induced DNA damage. | Scientific Reports

Figure 8: The role of CREB in TDCA-induced DNA damage.

From: Bile acid receptor TGR5, NADPH Oxidase NOX5-S and CREB Mediate Bile Acid-Induced DNA Damage In Barrett’s Esophageal Adenocarcinoma Cells

Figure 8

(A) Knockdown of CREB significantly decreased the tail moment in response to TDCA treatment in FLO-1 cells (N = 187–308 cells of 3 experiments). (B) Overexpression of CREB significantly increased the tail moment in response to TDCA treatment in FLO-1 cells (N = 171–369 cells of 3 experiments). These data suggest that CREB may mediate TDCA-induced DNA damage in FLO-1 cells. ANOVA **P < 0.0001, compared with Control siRNA group or pCDNA group; ##P < 0.001, compared with Control siRNA group plus TDCA group or pCDNA plus TDCA group.

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