Table 4 Diagnostic indices of epithelium, Bowman’s layer and stroma for sub-clinical keratoconus and keratoconus.

From: Value of corneal epithelial and Bowman’s layer vertical thickness profiles generated by UHR-OCT for sub-clinical keratoconus diagnosis

Indices

Normal

Sub-clinical KC

KC

mean

mean

P

AUC

cut off

Sen (%)

Spe (%)

mean

P

AUC

cut off

Sen (%)

Spe (%)

Epithelium

 EEI (%)

100.36 ± 3.11

92.06 ± 5.74

<0.001

0.928

97.82

91

87

76.11 ± 10.75

<0.001

1.000

93.88

100

100

 EEI-MAX (%)

94.22 ± 2.76

85.01 ± 6.31

<0.001

0.939

91.13

88

90

65.92 ± 12.00

<0.001

1.000

83.52

100

100

 EPV (μm)

2.87 ± 0.63

3.94 ± 1.04

<0.001

0.798

3.21

81

77

7.43 ± 2.64

<0.001

0.983

4.12

96

97

 EPSD (μm)

3.03 ± 1.18

4.17 ± 1.35

<0.001

0.754

3.54

66

70

8.56 ± 2.92

<0.001

0.987

4.29

100

97

Bowman’s layer

 BEI (%)

89.18 ± 6.62

77.10 ± 8.61

<0.001

0.870

84.10

81

77

59.50 ± 14.42

<0.001

0.980

75.49

89

100

 BEI-MAX (%)

78.55 ± 5.80

65.92 ± 8.89

<0.001

0.892

74.22

84

77

49.18 ± 13.48

<0.001

0.977

65.03

89

100

 BPV (μm)

1.30 ± 0.28

1.83 ± 0.45

<0.001

0.847

1.62

69

87

2.67 ± 0.99

<0.001

0.945

1.71

84

97

 BPSD (μm)

1.58 ± 0.51

2.48 ± 0.81

<0.001

0.766

2.02

72

73

3.88 ± 1.38

<0.001

0.934

2.85

94

97

Stroma

 SEI (%)

88.73 ± 2.15

88.93 ± 1.63

>0.05

0.529

89.27

70

53

80.33 ± 6.06

<0.001

0.944

86.91

95

83

 SEI-MAX (%)

73.02 ± 3.62

73.80 ± 2.39

>0.05

0.430

73.84

49

47

64.91 ± 6.73

<0.001

0.873

69.90

78

80

 SPV (μm)

53.97 ± 8.42

48.39 ± 5.62

>0.05

0.306

50.65

42

40

59.35 ± 10.90

=0.01

0.678

55.88

65

70

 SPSD (μm)

28.05 ± 16.03

35.48 ± 21.30

>0.05

0.586

31.73

55

70

54.58 ± 25.05

<0.001

0.832

38.11

76

83

  1. Normal, normal group; Sub-KC, sub-clinical keratoconus group; KC, keratoconus group; AUC, area under receiver operating characteristic curve; EEI, epithelium ectasia index; EEI-MAX, maximum epithelium ectasia index; EPV, epithelium profile variation; EPSD, epithelium profile standard deviation; BEI, Bowman’s layer ectasia index; BEI-MAX, maximum Bowman’s layer ectasia index; BPV, Bowman’s layer profile variation; BPSD, Bowman’s layer profile standard deviation; SEI, stroma ectasia index; SEI-MAX, maximum stroma ectasia index; SPV, stroma profile variation; SPSD, stroma profile standard deviation; Sen, sensitivity; Spe, specificity; P, P-value.
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