Figure 2
From: Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice
Reduced insulin sensitivity in K14-VEGF-C mice.
(a) Elevated fasting blood glucose and insulin levels in K14-VEGF-C mice, leading to higher homeostatic model assessment of insulin resistance (HOMA-IR) indices. (b) Intraperitoneal glucose tolerance test (n = 4–6 per group, mean ± SEM, ***p < 0.001 compared to WT control at the same time point with a two-tailed Student’s t-test) and insulin tolerance test (n = 7 per group, mean ± SEM, *p < 0.05 compared to WT control at the same time point with a two-tailed Student’s t-test). (c) Oil Red O and CD31 staining of liver sections (scale bars = 100 μm). (d) Quantification of triglycerides (TG) in liver and skeletal muscle tissues. Representative western blots (e) and corresponding quantification (f) of phosho-AKT and AKT in liver lysates of WT and K14-VEGF-C mice. *p < 0.05, **p < 0.01 and ***p < 0.001, two-tailed Student’s t-test. Data are mean ± SD.
