Table 1 In vitro cytotoxicity of by241 against several human cancer cell lines and two human normal cell lines.

From: Structurally novel steroidal spirooxindole by241 potently inhibits tumor growth mainly through ROS-mediated mechanisms

 

IC50 (μM)a

EC109

EC9706

KYSE450

MGC-803

BGC-803

SMMC-7721

ZIP77

MCF-7

PC-3

Het-1A

L-02

by241

5.62 ± 0.75

4.68 ± 0.67

8.73 ± 0.94

2.77 ± 0.44

1.18 ± 0.71

4.83 ± 0.68

2.71 ± 0.43

6.25 ± 0.80

6.36 ± 0.80

20.15 ± 1.50

21.80 ± 1.34

5-FU

9.31 ± 0.12

8.96 ± 0.33

nd

4.02 ± 0.27

2.23 ± 0.04

2.14 ± 0.25

3.32 ± 0.04

6.93 ± 0.03

15.03 ± 0.96

nd

4.37 ± 0.23

  1. aInhibitory activity was assayed by exposure for 72 h to substances and IC50 is the concentration of by241 required to inhibit the cell growth by 50% compared to an untreated control. Data are presented as the means ± SDs of three independent experiments; nd means not determined.
Back to article page