Figure 1
From: SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells
Sgo1 expression increases with neuroblastoma progression and SGO1 expression is elevated in MYCN-amplified neuroblastoma cell lines.
(a) Quantitative RT-PCR analyses of Sgo1 mRNA levels in precancerous lesions from four hemizygous MYCN-Tg mice (1.6 or 2 wks old), tumor lesions from three hemizygous MYCN-Tg mice (9 or 10 wks old) and three homozygous MYCN-Tg mice (6 or 6.1 wks old) and ganglia from three wild-type mice (1.6 or 2 wks old). (b) SGO1 mRNA (left upper : semi-quantitative, left bottom : quantitative qPCR analysis) and protein (right) levels in neuroblastoma cell lines.
