Table 2 Meta-analysis of the association between FCGR2A rs1801274 polymorphism and SLE risk.
Population | N | A vs. G(allele model) | AA vs. AG+GG(recessive model) | AA+AG vs. GG(dominant model) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
OR(95%CI) | POR | Ph | OR(95%CI) | POR | Ph | OR(95%CI) | POR | Ph | ||
Overall | 34 | 0.879(0.819–0.943) | 3.31 × 10−4 | 0.109 | 0.867(0.784–0.960) | 6.14 × 10−3 | 0.214 | 0.843(0.739–0.961) | 0.011 | 0.074 |
Caucasian | 12 | 0.845(0.766–0.932) | 8.08 × 10−4 | 0.439 | 0.775(0.655–0.917) | 3.08 × 10−3 | 0.522 | 0.883(0.756–1.032) | 0.117 | 0.427 |
Asian | 15 | 0.896(0.822–0.977) | 0.013 | 0.543 | 0.932(0.830–1.046) | 0.232 | 0.658 | 0.767(0.604–0.975) | 0.030 | 0.179 |
African | 3 | 0.853(0.642–1.132) | 0.271 | 0.438 | 0.836(0.428–1.633) | 0.601 | 0.192 | 0.802(0.515–1.250) | 0.331 | 0.688 |
Mixed population | 1 | 1.133(0.887–1.448) | 0.318 | — | 1.144(0.721–1.817) | 0.568 | — | 1.27(0.844–1.911) | 0.252 | — |
Non-Caucasian | 1 | 1.259(0.898–1.765) | 0.181 | — | 1.250(0.674–2.317) | 0.479 | — | 1.538(0.887–2.666) | 0.125 | — |
African Americans | 2 | 0.575(0.427–0.774) | 2.73 × 10−4 | 0.422 | 0.368(0.126–1.078) | 0.068 | 0.100 | 0.519(0.324–0.831) | 6.33 × 10–3 | 0.786 |
