Figure 3: Treatment with m336 antibody significantly inhibited MERS-CoV infection within the lungs. | Scientific Reports

Figure 3: Treatment with m336 antibody significantly inhibited MERS-CoV infection within the lungs.

From: Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

Figure 3

Lung specimens collected at day 2 after viral challenge were processed for assessing the viral titers by using both Vero E6-based infectivity assay and qRT-PCR targeting upstream E gene of MERS-CoV, and expressed as log10 TCID50/gram and log10 TCID50 equivalent (eq.)/gram, respectively. (A) Prophylactic and therapeutic efficacy of human m336 antibody treatment in reducing the lung titers of infectious virus. (B) Prophylactic and therapeutic efficacy of human m336 antibody in reducing the titers of viral RNA. The data shown are representative of at least two independently conducted assays using the same samples. Data is presented as Mean ± standard error (SE). ***P < 0.001 as determined by using Student’s t test.

Back to article page