Figure 1: Laquinimod rescues striatal, cortical, and corpus callosum atrophy in YAC128 HD mice. | Scientific Reports

Figure 1: Laquinimod rescues striatal, cortical, and corpus callosum atrophy in YAC128 HD mice.

From: Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

Figure 1

Striatal and cortical atrophy was assessed by structural MRI in the caudate-putamen, and five different areas of the cortex (A). Vehicle-treated YAC128 mice presented striatal atrophy compared with vehicle-treated WT mice as measured by structural MRI (B) and stereological assessment (H). Treatment with the highest dose of laquinimod (10 mg/kg) rescued striatal atrophy in YAC128 mice (A,H). Vehicle-treated YAC128 mice displayed cortical atrophy in the piriform (C) cingulate (E) and retrosplenial (F) areas of the cortex as measured by structural MRI. Treatment with laquinimod rescued cortical atrophy in the piriform (C) cingulate (E) and restrosplenial (F) areas of the cortex in YAC128 HD mice. Laquinimod-treated (10 mg/kg) YAC128 mice increased significantly the volume of the cingulate (E) and somatosensory (G) cortical regions compared with vehicle-treated YAC128 mice. Also, vehicle-treated YAC128 HD mice presented atrophy in the corpus callosum (CC) compared with vehicle-treated WT mice as measured by stereological assessment (I). Both doses of Laquinimod rescued CC atrophy in YAC128 mice (I). (B) Values shown as percentage of total brain volume ± SEM; n = 9 WT-vehicle, n = 6 YAC128-vehicle, n = 8 YAC128-laquinimod (1 mg/kg), n = 8, YAC128-laquinimod (10 mg/kg); *p < 0.05, ***p < 0.001, paired two-tailed Student’s t-test. CPu – caudate-putamen. (C,D,F) Values shown as mean ± SEM; n = 9 WT-vehicle, n = 7 YAC128-vehicle, n = 6–8 YAC128-laquinimod (1 mg/kg), n = 8, YAC128-laquinimod (10 mg/kg); *p < 0.05, **p < 0.01, ***p < 0.001 by one-way ANOVA with Tukey’s post hoc analysis. (E,G) Values shown as mean ± SEM; n = 9 WT-vehicle, n = 7 YAC128-vehicle, n = 6–8 YAC128-laquinimod (1 mg/kg), n = 8, YAC128-laquinimod (10 mg/kg); *p < 0.05 by paired two-tailed Student’s t-test. (H,I) Values shown as mean ± SEM; n = 9–10 WT-vehicle, n = 15–16 YAC128-vehicle, n = 18–19 YAC128-laquinimod (1 mg/kg), n = 20–21 YAC128-laquinimod (10 mg/kg); *p < 0.05, **p < 0.01 by paired two-tailed Student’s t-test. LAQ – laquinimod. CC – Corpus Callosum.

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