Figure 2: Laquinimod improves white matter microstructures in YAC128 HD mice. | Scientific Reports

Figure 2: Laquinimod improves white matter microstructures in YAC128 HD mice.

From: Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

Figure 2

Analysis of white matter microstructural changes by diffusion tension imaging (DTI) revealed a regionally dependent decrease of FA values in vehicle/laquinimod-treated YAC128 mice compared with vehicle-treated WT mice (A,B) (red-yellow indicates higher FA values in vehicle-treated WT mice; blue-light blue indicates lower FA values). Treatment with the lowest dose of laquinimod (1 mg/kg) increased FA values in the posterior CC (B middle panel) but not in the anterior CC or cingulum (B right and left panel, respectively). No effects on FA values were observed using high dose laquinimod (10 mg/kg) (B). Parallel (Dp) and radial (Dr) diffusivity were also investigated but no differences were observed between vehicle- or laquinimod-treated YAC128 HD mice compared to vehicle-treated WT mice (C,D). (B–D) Values shown as mean ± SEM; n = 8 WT-vehicle, n = 7 YAC128-vehicle, n = 8 YAC128-laquinimod (1 mg/kg), n = 8, YAC128-laquinimod (10 mg/kg); *p < 0.05, **p < 0.01 by one-way ANOVA with Tukey’s post hoc analysis; CC – Corpus Callosum. LAQ – laquinimod.

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