Figure 3: Effect of laquinimod on interleukin-6 levels in serum of YAC128 HD mice. | Scientific Reports

Figure 3: Effect of laquinimod on interleukin-6 levels in serum of YAC128 HD mice.

From: Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease

Figure 3

Vehicle-treated YAC128 HD mice presented increased serum levels of interleukin-6 (IL-6) compared with vehicle-treated WT mice. Low dose laquinimod (1 mg/kg) reduced the levels of serum IL-6 in YAC128 HD mice, whereas no effect was observed with high dose laquinimod (10 mg/kg). Values shown as mean ± SEM; n = 8 WT-vehicle, n = 16 YAC128-vehicle, n = 15 YAC128-laquinimod (1 mg/kg), n = 18 YAC128-laquinimod (10 mg/kg); *p < 0.05 and n.s. = not significant (compared with vehicle-treated WT) by paired Student’s t-test. LAQ – laquinimod.

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