Figure 5 | Scientific Reports

Figure 5

From: MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis and potentiates antineoplastic effect of cisplatin in ovarian cancer

Figure 5

MPT0G066 potentiates antineoplastic effects of cisplatin in ovarian cancer in vitro.

(A) SKOV3 and (B) A2780 cells were incubated with MPT0G066 (0.01–0.3 μM) and cisplatin alone or increasing concentration (1.25–20 μM) for 48 h. Left panel: cell viability was determined by MTT assay. Right panel: CI values for combination of MPT0G066 and cisplatin. The resulting combination index (CI) theorem of Chou-Talalay offers quantitative definition for additive effect (CI = 1), synergetic effect (CT > 1) and antagonism effect (CI < 1) in drug combinations. Fa represented fraction of cells affected.

Back to article page