Figure 6 | Scientific Reports

Figure 6

From: MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis and potentiates antineoplastic effect of cisplatin in ovarian cancer

Figure 6

MPT0G066 suppresses human ovarian carcinoma growth and potentiates antineoplastic effects of cisplatin in ovarian cancer in vivo.

SKOV3 and A2780 xenograft nude mice were orally (po) treated with MPT0G066 (200 mg/kg) daily or intravenously (iv) administered cisplatin (5 mg/kg) once a week or combination or vehicle after tumor cell implantation. Tumor volume and Body weight of SKOV3 and A2780 xenografts were shown in (A,B). (C) Formalin-fixed paraffin-embedded sections from SKOV3 and A2780 were stained with H&E stain and phosphorylated JNK (Thr-183 and Tyr-185) antibody. The stained sections were used 200X magnification to observe via microscope.

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