Figure 1
From: Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model
NRG1 improves deficits in Morris water maze behavioral task in APP mice.
Eight weeks after stereotaxic injection of female LV-Control, LV-NRG1/I or LV-NRG1/III mice, cognitive function was assessed by the Morris water maze (N = 6). Mice were trained on the visible platform and then tested for spatial learning. Linear regression analysis shows the slope for the latency (A) and distance (B). Latency or distance across all four trials daily from days 1–3 for visible platform and from days 4–7 for hidden platform was calcuated and expressed as mean ± SEM. A main effect for treatment was observed for latency (C) and distance traveled (D). *p < 0.05, **p < 0.01, ***p < 0.0005.
