Figure 4
From: Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer’s disease model
Aβ load is decreased by type I and type III NRG1.
(A) Representative immunostaining for plaques on sections of the hippocampus of non-Tg and APP-Tg injected with LV-control, LV-NRG1/I or LV-NRG1/III. (B) The area of neuropil occupied by Aβ-immunoreactivity was calculated from 9 randomly selected sections per mouse (N = 3). (C) Western blotting analysis of protein extracts of the hippocampus using anti-Aβ antibodies 6E10. β-actin was used for protein loading control. (D) Normalized levels of Aβ show a marked decrease by LV-NRG1/I and LV-NRG1/III. The results were expressed as mean ± SEM. *p < 0.05; **p < 0.01;***p < 0.0005, NS, not significant.
