Table 1 In vitro antiviral activity of analogs in the MADTP series against CHIKV and VEEV.

From: The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

Species

Virus (strain)

MADTP-314

MADTP-372

MADTP-393

CHIKV

899 (lab)

26 ± 11a

2.6 ± 1.0a

18 ± 6.4a

Venturini (Italy 2008)

26 ± 2b

1.4 ± 0.01b

8.2 ± 2.2b

Congo 95 (2011)

6.4 ± 0.1b

0.75 ± 0.4b

1.4 ± 0.3b

VEEV

TC83

>40b

6.8b

35 ± 10b

  1. aCPE reduction, bviral RNA reduction. VEEV: Venezuelan equine encephalitis virus. Data shown are average values ± SD of at least two independent experiments. CC50 values for MADTP-314, MADTP-372 and MADTP-393 on Vero cells are >743 μM, >668 μM and 57 ± 28 μM, respectively.
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