Table 2 In vitro anti-CHIKV activity of MADTP molecules against WT and resistant CHIKV variants.
From: The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection
EC50 (μM) | Resistance selection | Reverse genetics | ||
|---|---|---|---|---|
WT 899 | MADTP-314res variant 3 | WT LS3 | LS3-P34S | |
MADTP-314 | 26 ± 11 | 283 ± 45 | 40 ± 5.0 | >500 |
MADTP-372 | 2.6 ± 1.0 | 255 ± 16 | 4.9 ± 0.6 | >50 |
MADTP-393 | 18 ± 6.4 | 193 ± 14 | 15 ± 0.8 | >50 |
Chloroquine | 18 ± 11 | 20 ± 4.7 | n.d. | n.d. |
T-705 | 20 ± 2.7 | 34 ± 5.7 | n.d. | n.d. |
