Figure 2: Cholestasis-induced inflammation and fibrosis are exacerbated in livers of animals with simple steatosis. | Scientific Reports

Figure 2: Cholestasis-induced inflammation and fibrosis are exacerbated in livers of animals with simple steatosis.

From: Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport

Figure 2

(A) Hepatic MPO activity. (B) Hepatic edema. (C) Semi-quantitative analysis of H&E-stained sections. Statistical analysis was not performed on scores for confluent necrosis and neutrophil influx because ranges were confined to one value. (D) Representative liver histology. Upper panels, H&E staining; lower panels, picrosirius red staining; small arrows, macrovesicular steatosis; encircled, discrete periportal ductular reaction; large arrows, confluent necrosis; dotted line, porto-portal septal fibrosis. Neutrophil influx was associated with confluent necrosis (E) and ductular reaction (F). Black arrowheads, nucleus of inflammatory cell; white arrowhead, nucleus of hepatocyte. Values represent n = 5–6/group; histological scoring data are reported as median (range), other data as means ± SD; 1, p < 0.05 versus sham; 2, p < 0.05 versus MCD; 3, p < 0.05 versus BDL; 4, p < 0.05 versus MCD+BDL.

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