Figure 3: Dysregulation of bile salt synthesis in animals with combined steatosis and cholestasis. | Scientific Reports

Figure 3: Dysregulation of bile salt synthesis in animals with combined steatosis and cholestasis.

From: Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport

Figure 3

(A) Plasma total bilirubin, plasma bile salt levels, and hepatic bile salt levels. Statistical analyses shown were performed on total bile salt levels. (B) HepG2-NTCP cells treated with bile salts at 200 μmol/L in total were assayed for viability, abundance, and release of AST and LDH. (C) Hepatic mRNA of Cyp7a1 and nuclear receptors that suppress Cyp7a1. Values represent means (n = 4–6) ± SD; 1, p < 0.05 versus sham; 2, p < 0.05 versus MCD; 3, p < 0.05 versus BDL; *p < 0.05.

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