Figure 4: Gene expression of hepatic bile salt and bilirubin transporters is modulated in animals with combined steatosis and cholestasis. | Scientific Reports

Figure 4: Gene expression of hepatic bile salt and bilirubin transporters is modulated in animals with combined steatosis and cholestasis.

From: Simple steatosis sensitizes cholestatic rats to liver injury and dysregulates bile salt synthesis and transport

Figure 4

(A) Hepatic mRNA of basolateral transporters that import bile salts and bilirubin from the circulation. (B) Hepatic mRNA of canalicular transporters that excrete bile salts and bilirubin into the biliary system. (C) Hepatic mRNA of basolateral transporters that export bile salts and bilirubin into the circulation. Values represent means (n = 5–6) ± SD; 1, p < 0.05 versus sham; 2, p < 0.05 versus MCD; 3, p < 0.05 versus BDL.

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