Figure 1 | Scientific Reports

Figure 1

From: TGF-β/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease

Figure 1

Imbalance of circulating Treg and Th17 cells in patients with COPD.

(a) Lymphocytes were gated on FSC-A versus SSC-A plots and CD4+ T cells were identified based on their expression of CD3 and not CD8. (b) Representative flow cytometric dot-plots of Treg and Th17 cells in peripheral blood. (c) Comparisons of Treg and Th17 cell percentages in peripheral blood from healthy controls (HC, n = 27), healthy smokers (HS, n = 24) and COPD patients (n = 29). (d) qRT-PCR analysis of Foxp3 and RORC gene expression in peripheral CD4+ T cells of HC subjects (n = 10), HS subjects (n = 10) and COPD (n = 10) patients. The data are represented as the mean ± SEM; a value of P < 0.05 was considered statistically significant.

Back to article page