Figure 3 | Scientific Reports

Figure 3

From: AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-κB and STAT3 Pathways

Figure 3

Effects of AAV8-mediated ACE2 delivery on retinal function in EAU mice.

To determine the effects of over-expression of ACE2 on retinal function, both dark-and light-adapted ERG were recorded in EAU mice at the 14th day after immunization. For dark-adapted ERG, the stimulus light intensity ranged from −3.0 to 1.0 (log cd-s/m2). For light-adapted ERG, the stimulus light intensities were 0.0 and 1.0 (log cd-s/m2). (a) Representative ERG responses in the AAV8-ACE2+EAU, AAV8-eGFP+EAU, EAU and naïve groups. (b) Dark and light-adapted ERG amplitudes vs. intensity profile was shown. Data were shown as mean ± SEM (*p < 0.05, **p < 0.01, ***p < 0.001 versus AAV8-eGFP+EAU group; #p < 0.05, ##p < 0.01, versus EAU group; n = 7~10 per group).

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