Figure 4 | Scientific Reports

Figure 4

From: AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-κB and STAT3 Pathways

Figure 4

Real-time PCR analysis of retinal mRNA expression for inflammatory cytokines in the AAV8-ACE2 treated EAU mice.

Retinas were collected for analyzing the mRNA levels of the pro-inflammatory cytokines IL-6, IL-1β, TNF-α, MCP-1 and anti-inflammatory cytokine IL-10. Values on y-axis represent fold difference of the mRNA expressions at the 14th day after IRBP immunization. The mRNA levels of the pro-inflammatory cytokines were significantly decreased, whereas the expression of IL-10 was remarkably increased in the AAV8-ACE2+EAU group compared with the AAV8-eGFP+EAU and the EAU groups (*p < 0.05, **p < 0.01, ***p < 0.001). Data were expressed as mean ± SEM (n = 4–6 per group).

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