Figure 1

A high K⁺ seizure model triggers less seizure-like activity at puberty: Reversal by α4 knock-out.

(a) Representative 20 min traces illustrating the predominant response to 8.5 mM K⁺ for each group. Left, pre-pubertal WT, middle, pubertal WT, right, pubertal α4−/−. (b) Expansion of the time-base for indicated regions (blue arrow). (c) Averaged coastline length, a measure of neuronal activity, reveals greater activity pre-pubertally and in the pubertal α4−/−. *ANOVA, F(2, 32) = 3.50, P = 0.042 vs. other groups (100 s after 8.5 mM K⁺). (d) Percent of slices exhibiting seizure-like activity. *P = 0.005 vs. other groups, χ²  =  10.6, DF = 2. (n = 7 mice, α4−/−; n = 14 mice, WT Pre-pub; n = 14 mice, WT Pub).