Figure 2
From: Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus
THIP selectively reduces spontaneous discharge in high K+ at puberty.
(a,b) Representative traces of spontaneous synchronized discharges recorded in 8.5 mM K+ from pre-pubertal (a) and pubertal (b) CA1 hippocampus before and after 1 μM THIP, which is selective for δ-GABARs. (c) Expanded time-base of traces (Pub) presented in (b). (*individual event from indicated trace) (d), Averaged values of the coastline length, #slices/group, n = 19 slices from 10 mice, Pre-pub; n = 15 slices from 10 mice, Pub. *(1-tail) paired t-test, t(14) = 7.26, P = 2.07 × 10−6 vs. pre-THIP. (e) Averaged ratios of the coastline length (CLL) for THIP relative to the pre-drug control. (2-tail) t-test, t(32) = 3.46, *P = 0.0016 vs. pre-pub.
