Figure 3
From: Pubertal Expression of α4βδ GABAA Receptors Reduces Seizure-Like Discharges in CA1 Hippocampus
DS2 selectively reduces spontaneous discharge in high K+ at puberty.
(a,b) Representative traces of neuronal activity recorded in 8.5 mM K+ from pre-pubertal (a) and pubertal (b) CA1 hippocampus before and after 10 μM DS2, a GABA modulator which is selective for δ-GABARs. (c) Expanded time-base of traces (Pub) presented in (b). (*individual event from indicated trace) (d), Averaged values of the coastline length, *(1-tail) paired t-test, t(16) = 6.8, P = 2.15 × 10−6 vs. pre-DS2. (e) Averaged ratios of the coastline length (CLL) for DS2 relative to the pre-drug control. *(2-tail) t-test, t(33) = 3.85, P = 5.1 × 10−4 vs. pre-pub. n = 18 slices from 9 mice, Pre-pub; n = 18 slices from 9 mice, Pub.
